Helped Over 500,000 patients with 98%+ satisfaction.

Connect & Get Personalized 1-to-1 Answers from Expert Doctors

DoctorSpring > Question Home

Does high TELOPEPTIDE MARKER indicate BONE CANCER?

Resolved Question:

My telopeptide markers in my urine are a bit high. My other bone turnover markers are all good. For example, bone specific alkaline phosphatase was 26.3 (range should be 14.2-42.7).
I have very dense bones, so I would think these should be low. However I am 58, so maybe that's why they are raised.

collagen cross-linked n-telopeptide (NTX) is 86 (should be 4-64)

collagen type 1 c-telopeptide (ctx) is 529 (should be 40-465)

1.Do you think these indicate bone cancer?

2. Do you think A/C chemotherapy can increase bone turnover?
 

Category: Oncologist

Ask Your Own Question

Category: Hematologist
 28 Doctors Online

Thank you for your query at DoctorSpring.com.
Dear patient,
These markers can be elevated in many conditions and not very specific for cancer. These will be elevated in all conditions where there is a bone remodeling occurring irrespective of the bone. considering your age, prior (dense) bone condition, normal marker levels, negative scans and asymptomatic status, I definitely would not consider metastases to bone now.
Kindly be assured that there is no sign of any bone spread at this point of time.
Feel free to ask queries.
Kind regards.


Patient replied :

I'm worried about cancer getting worse during chemo. I've heard it can actually spread or get bigger. In what cases does that happen? Is it likely to happen in my case?


Hello. Thank you for writing to us again.
A responding cancer will not get worse during chemotherapy. If tumor grows it will be obviously evident. There are no specific conditions which can be cited here. This is very unlikely to happen in your case due to high ER positive status.
Feel free to discuss further,
Regards


Patient replied :

Thank you.
Question #1: Why does the high ER positive status prevent the tumor from growing during chemo?
Question #2: Also, it occurred to me that since the cancer is lobular, and divides slowly, it could grow during chemo, because the chemo only works on quickly dividing cells.
Thank you.


Hello. Thank you for writing to us again.
This implies more technical medical answer which is very difficult to explain over email consult. This needs to be personally explained to you with each step of normal and cancer cell cycle pathways with lucid explanations.
A possible short answer:
1. High ER is a marker of good prognosis due to slow growth
2. This does not mean chemo does not act on slow growing cells. Chemo acts by causing DNA damage which kills the cells during subsequent cell replication.
Feel free to discuss further,
Regards


Patient replied :

So am I correct in saying that it is highly unlikely that my cancer will progress or metastasize during chemo?


Yes. A regressing / responding tumor will not metastasize during chemo.


Dr. Prasad Eswaran
Category: Hematologist
Experience: 
Doctorate in Medicine (Fellowship in Oncology), DM,  Madras Medical College & Govt. General Hospital, Chennai, India.

Doctor of Medicine (Residency in Radiation Oncology) , MD, Christian Medical College, Vellore, Tamilnadu, India, 2004-06.

Diploma in Medical Radiology & Therapy (Residency in Radiation Oncology), D.M.R.T, Madras Medical College & Govt. General Hospital, Chennai, India, 2004-06.

Bachelor of Medicine & Bachelor of Surgery - M.B.B.S, Govt. Stanley Medical College & Hospital, Chennai, India, 1998-2004.
Dr. Prasad Eswaran and 4 other Medical Specialists are ready to help you

Users who read this, also read:

Make informed and better medical decisions.

Join the 500,000 people who found a smarter, quicker way to get Answers, Recommendations & Expert Opinions.

Expert Doctors at fingertips

Recommendation on next step. Second-opinion.Multi-specialty.

Save Time

Average time for answers: 6 hours.

Save Money

$35 for typical specialist consult vs. $120 for a local appointment.

Free Follow-ups

Clarify, ask further questions for free in private conversation.

100% Satisfaction

Money back guarantee for the 1st reply. MEDNET Quality Board.

Start My Consultation

CHAT NOW

About DoctorSpring.com

Doctor Spring is a novel online Doctor consultation platform where you can get your medical questions answered by leading Doctors. Just Submit your question and rest assured that you will consult a Doctor easily. Once you submit the question, the Doctor from the concerned specialty will reply within hours. You can always ask more questions or add details with follow-up question options and make it an online doctor chat. You may use this service to consult a specialty or for getting medical second opinion. All paid services come with a MEDNET quality assurance and 100% money back guarantee.

DoctorSpring in news