PCOS

Resolved question:
I have pcos and was prescribed clomid, two cycles and they both didn't work. I am yes typically with symptoms of pcos and am very overweight. I had a progesterone level of 3 the first time round using clomid, 50mg and second time round 100mg had a progesterone level of 2.4, day 21. I am currently on cd44 and just over a week ago have felt like my menstrual cycle was about to start, sore breasts and menstrual cramps. But no period has arrived! Now the cramps are intermittent but gradually becoming worse. More sharp. I have informed my gp says no to worry but I'm concerned as definitely not pregnant and keep getting these awful cramps. I also am suffering dizzy spells. Do I need to be concerned?

Submitted: 4 Days
Category: Family Physician-GP

Expert:  Dr. Jaydeep Tripathy replied 4 Days.

Hello,
Thank you for choosing Doctor Spring.Sore breasts and cramps are common with use of clomid, but if you are experiencing severe cramps that would require a more detailed examination by your OB/GYN. For better assessment I would like to know additional information on the following:

1. Was a follicular study done to confirm ovulation and has ovulation happened?
2. What investigations have you undergone?
3. What is the indication for cd44?

You can reply as a follow up.
Thank you.

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Patient replied :

Ok I did not ovulate as a scan of the follicles was not completed rather a progesterone blood sample was taken at cd21 which was a 2.4 indicating no ovulation. I have higher testosterone levels and ultrasound shown polycystic ovary syndrome. Cd 44 is the date since I took clomid, day one since the cycle started ( induced by northisterone) and no ovulation has occurred this cycle. The cramps are worse than when they started, feels like I want to start my period. Ut going on two weeks now there is no sign of it coming. I took the clomid on the 28/11/2013 but no period since yet all signs of it coming. Is it ok to take the northisterone to bring on menses as this may help relieve the symptoms?


Expert:  Dr. Jaydeep Tripathy replied 3 Days.

Hello,
Thanks for writing back to us. No you should not take norethisterone for inducing periods before getting evaluated by your doctor. Clomid cycles can be repeated and the dose can be increased depending upon the requirement, so titration is required in your case for optimal result.

You need to get in touch with your OBGYN for ultrasound to rule out ectopic pregnancy. As, ectopic pregnancy can present with negative pregnancy test and severe cramps and pain in the abdomen.

There is a possibility of you ovulating but not enough of progesterone is produced(luteal phase deficiency) to support the pregnancy. So it is important to get a follicular study after you start a new cycle of clomid(with dose adjustments) and check if you require progesterone supplementation.

I would recommend that you get in touch with your OBGYN for the following:
1. Ultrasound to rule out ectopic pregnancy.
2. Blood test for pregnancy for accurate results.
3. Dose adjustments for clomid.
4. Follicular study after staring a new cycle of clomid.
5. Progesterone estimation and supplementation if required.

Hope this helps.
Do write to us for follow ups.
Thank you.

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Patient replied :

Thanks for your help. Lauren



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