Hi, Doctor! I was diagnosed with type 2 diabetes in February, 1999 and I am being treated for hypertension; both conditions are presently controlled. I am taking Metformin, 2000 mg twice daily, Actos 30 mg once daily, Metoprolol 100 mg once daily,Triamterene 37.5-25 once daily, Lotrel 10/40 once daily, Lipitor 10 mg once daily and Ranexa 500 mg once daily. On August 25, 2014 I submitted blood and urine that returned September 9 with decreased eGFR (57) and slightly increased creatinine (1.35) and calcium (10.6). I was also mildly anemic (RBC 4.10, Hemoglobin 12.1 and Hematocrit 36.2). Urine virtually free of presence of protein (1.3), I told my family physician that, for ethical reasons, I had stopped eating meat 9 months before. I also began waling daily in January 2014 and lost 36 lb (I had weighed 250 lb and got down to 214). My Doctor thought eGFR/creatinine might be due to dehydration and anemia to absence of meat in my diet. She instructed me to drink 8 glasses of water and to add chicken/fish to my diet and she had me come in biweekly to get B-12 injections. She tested me again last week. I received my results today which showed eGFR dropped further to 49 and creatinine was 1.54.Slightly improved calcium (10.4). Anemia still present but a little better from last time (RBC 4.19, Hemoglobin 12.5 and Hematocrit 37.7). Urine still largely free of proteins (1.9). I lost another six lb.; down to 208 lb. My Doctor has now cut my daily Metformin dosage in half (2000 mg to 1000 mg) and reduce Lotrel (from 10/40 to 10/20). She instructed me to return in one month (instead of the usual three) for retest. Please let me add that on November 3 I had ultrasound done on my kidneys (I have history of kidney stones) and urologist advised that there was no indication of scarring or necrosis in my kidneys. I'm a 59 year old caucasian male. Doctor, can Metformin and Lotrel elevate creatinine and reduce eGFR if taken over time? In your judgement, could Metformin be the source of my test results? And can reducing Metformin and Lotrel resolve these issues? I'm frightened that I may indeed have kidney disease-please give me your impression/judgement of the history I've described above...thank you and G-d bless you. Please don't misunderstand; my Doctor is wonderful-I'm reaching out to you because of my own anxieties...