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Can CLOMID increase ESTROGEN in men and cause depression?

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Dear doc,
24 yr old male diagnosed with low testosterone. My endo perscribed me clomid 25 mg a day to get my levels up. Have been on it for three days but have felt terrible. Very emotional and semi depressed. I read clomid can increase estrogen in men is this possibly what I'm feeling?

Category: Endocrinologist

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Category: Diabetologist
 31 Doctors Online


Thank you for your query at

The mechanism of action of clomiphene to increase Testosterone levels, also may lead to these side effects that you are experiencing. Not due to estrogen.

However, in your case, it will be better if Testosterone replacement is given, unless your sperm counts require treatment and you contemplate having children in near future. Testorenone supplementation will not have such side effects.

Also, further tests such as LH, FSH, Prolactin; are required to know the cause of your low Testosterone.

I hope this was helpful. Let me know if you have any further queries.

Thank you.

Patient replied :

Thank you I spoke to my endocrine who and decided to discountiue clomid and begin androgel. Still not feeling great however wondering how long it takes for the clomid to wash out of your system?

Thanks for choosing
Give it 1-2 weeks. And let the optimum effects of Androjel to set in.

Dr. J Muthukrishnan
Category: Diabetologist
1. 10th Asia-Pacific Pediatric Endocrine Society  Fellows meeting, Seoul, Korea, Oct 2008
2. Eighth ICMR Course on Genetics and Genetic Counseling – Jul 2008 – SGPGI, Lucknow
3. Annual Certificate Course on Endocrinological Laboratory Techniques at National Institute of Nutrition (ICMR) Hyderabad,India, ( Aug-Sep 2006) 
Fellowship: Endocrinology, Diplomate of National Board, National Academy of Medical Sciences, New Delhi, 2008, Medwin Hospital, Hyderabad
Senior Residency: Diplomate of National Board (General Medicine), National Academy of Medical Sciences, New Delhi, 2002
Residency: MD, General Medicine, 1997-2000, Armed Forces Medical College, 2nd position in University
Medical School: MBBS, Armed Forces Medical College, 1992
Dr. J Muthukrishnan and 4 other Medical Specialists are ready to help you

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