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Feeling very tired with raised ALP level in blood.

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I am very scared. I am a 50 year old female. I had blood work because I was feeling tired. My ALP was 216. I have had a hysterectomy but no other issues. I am on antidepressants. Also they said my Iron was low which I take a supplement and my B12 was high. I feel tired but that is the only system I seem to have. I have been reading about the things it could be and it scares me.

Category: Gastroenterologist, Medical

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Category: Hepatologist
 28 Doctors Online

Thank you for your query at
I understand your concern.
ALP is a very non specific marker, and does not really point towards any particular disease. Was the LFT done along with it? Can you please attach all the test results for me to review?
By low iron, if the hemoglobin level is too low, it can be the reason for your persistent fatigue.
Please let me review your entire report and I will get back to you.

Patient replied :

Please find attached my labs. If you can not read a specific line let me know and I will let you know specifically what it reads.

I have reviewed your reports.
Your cholesterol level is slightly high, iron levels are low, and B12 is high.
ALP is also high, but as I said, it is a very non-specific marker.
I would request you to get a peripheral smear done and follow-up.
It could be indicative of SIBO ( Small Intestinal Bacterial Overgrowth ), where typically the B12 will be high, iron levels low, and there will be persistent fatigue throughout the day.
Please do not worry, there is no cause of concern.
Let me review your peripheral smear, and based on that I will guide you further.

Patient replied :

So is the ALT high in your opinion? it says it is on the sheet. You don't think I have liver cancer? What is a small bacterial overgrowth? Thank you for your help. Also would these labs be indicative of a bile duct obstruction.

I went through the lab report.
Your alkaline phosphatase is only mildly increased. There are many different causes for the rise in alkaline phosphatase. One of the common causes is obstruction to the flow of bile from the liver. Other common source is bone.
I would advise you to get an ultrasound scan of the abdomen done (if not done already) to see if the bile ducts are normal..
Please get back to me with the ulatrsound scan of the abdomen report.

Patient replied :

I will certainly do that right away. So by what you have seen you don't see anything that might be serious like cancer or hepatitis. Thanks for your expert help.

No it doesn't seem like cancer. Take care.

Dr. Ratnakar Kini
Category: Hepatologist
Fellowship - DM - TN Dr.MGR Medical UniversityResidency - TN Dr.MGR Medical University Medical School - Stanely Medical College, TN Dr.MGR Medical University
Dr. Ratnakar Kini and 4 other Medical Specialists are ready to help you

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