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Fever, joint pain after taking IRON for low HEMOGLOBIN.

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My sister is 26 year old and has very low haemoglobin. It was around 9-9.5 and we thought of consulting doctor. Around 3 months ago Doctor put her on iron tablets. After few days she developed severe joint pain (knees, shoulders and neck) and they even started swallowing. She also started getting a lot of fever (of the order of 102-103). At the same time doc conducted one blood test and her esr was found elevated. She was then put on calcium tablets. Her joint pain has definitely reduced but since then she has been suffering from frequent fevers (once in around 5 days that too after taking regular medicines). Also, her ESR level reached very high levels(recent result shows 140 mm/lst hr).
The doctor conducted few tests for artheritis but all were negative. Chest X-Ray and Ultrasound (abdomen) too didn't reveal anything. Everything was fine. Apart from elevated ESR (140) and low Hb (8.6), everything was normal in her latest blood report including (WBC, TLC, platelet count, leucocyte count ).
It has been around 1.5 months that these cycles of fever has been going on. A slight increase in pus cells were reported in one of the urine tests but nothing else. I also observed that she gets fever as and when she feels little restless and the fever accompanies with pain in her one of the knees.
We are completely clueless about all these proceedings . Could you please advise regarding this and let us know what probably could be the reason behind this.
Attaching her latest blood report.


Category: Internal Medicine Specialist

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Category: HIV- AIDS Specialist
 24 Doctors Online

Thank you for your query at
There is very little information in terms of investigations for suspected connective tissue disorder. It points towards a connective tissue disorder from the history.
I would request you to get Vit B12, Ferritin, serum Iron status, ANA by immunoflourescence, C- Reactive protein levels, ANTI CCP, Rheumatoid Factor, This would be minimum on which we require to build our case.
It takes one working day to get all the reports. In all probability to rule in or out connective tissue disorder would be high on priority.

Dr. Jaydeep Tripathy
Category: HIV- AIDS Specialist
MBBS from Sri Ramachandra University in December 2011
M.Med (Family Medicine) - TNMGR University, Chennai
MBA-MPH in Public Health in March 2016, SRM University
Finished AFIH in March 2016, SRM University
MRCP ( UK ), Internal Medicine, Royal College of Physicians, June 2016
Fellowship in Diabetology from Martin Luther University in January 2017

Currently Resident Physician, in MD Radiodiagnosis - Kamakshi Memorial Hospital, Chennai
Dr. Jaydeep Tripathy and 4 other Medical Specialists are ready to help you

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