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Rebound pain in throat after swallowing under PPI.

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41 year old female. non smoker (ex smoker) , healthy weight and diet. 10+year history of reflux disease. Currently on 40mg of protonix for about 2.5 years. Ppi definitely decreased the severe symptoms of globus, regurgitation and upper epigastric pain was having. The last couple weeks I have had some weird symptoms. Sore throat on and off for a week without a cold. Now the last two days, the troubling symptom started in the middle of the night two days ago. When I eat certain foods (anything that is harder than soup, or is not liquid or really soft). I chew the food and swallow it. I complete the swallow fine with no issues, but IMMEDIATELY after the swallow finishes, there is a rebound pain in the lower part of my throat. Almost as if it's that food passing through and touches that spot in my throat. It is gone as quickly as it comes. It's not every time, or every food. I am terrified. I have no actual trouble swallowing, just the pain about 70% of the time. I have a great deal of lifelong anxiety surrounding my throat, and I've been reading a lot about throat cancer. Is it possible my Ppi has stopped working?

I should also add that the last week or so, I have the feeling of globus back again, unrelated to eating and only on and off. The swallowing pain I described above though is absent all other times.

Category: ENT Specialist

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Category: ENT Specialist
 30 Doctors Online


Thanks for posting your query at

I can understand your problem.

You are suffering from reflux symptoms since 2.5 years. Now you have pain on swallowing for solid food. These symptoms also may be related to reflux (reflux related ulcer or inflammation may cause similar symptoms. Still to confirm the diagnosis you need examination by ENT surgeon or gastroenterologist . They can plan for endoscopy(camera test) for you hypopharynx(part of throat) and food pipe(oesophagus). This will help in getting correct diagnosis and so you will able to get correct treatment also.
To control you reflux symptoms you need life style changes along with PPIs-
Avoid very spicy food.
Avoid fast food/coffee or tea
Drink plenty of water.
Morning and evening walk
Don’t lie down immediately after lunch or dinner
Use head end elevation of pillow( prevent reflux symptoms)
Continue PPIs.
Hope this helps

Best regards

Dr. Sunil Jalan

Dr. Sunil Jalan
Category: ENT Specialist
DAA (Diploma in asthma and allergy) : Christian Medical College, Vellore, 2012
D.N.B (ENT), 2011
Residency - M.S. (Master post graduate degree in otorhinolaryngology),  Christian Medical College, Vellore, 2009
D.L.O. (Diploma in otorhinolaryngology) - Christian Medical College, Vellore, 2007
Medical School - M.B.B.S, S.P. Medical college, Bikaner, 2004
Dr. Sunil Jalan and 4 other Medical Specialists are ready to help you

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