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Considering the information you have provided, (STD free, Condom use+) it is safe to go for Anal sex. There is no long term complications for your or your partner if you take proper STD precautions.
Do keep in mind to use lubricants liberally. Do not moving from anal to vaginal sex without first changing condoms. There might be slight pain and discomfort initially. However if there is tearing pain, sever discomfort for your partner you should not proceed with it.
Generally it is safe.
Hope this helps
Feel free to ask followups.
Patient replied :
Thanks for your reply. Do you have any recommendation on how to reduce the pain and discomfort (besides lubricant and foreplay)? The last time we had anal sex she was in a lot of pain even though she did not ask me to stop.
Also, she told me that she is scared which makes her tense the muscle unintentionally. She was asking whether there is any medication she can take (preferably OTC) to help her relax her mind and body.
The anal muscle and (sphincter) should relax for the experience to be painless. Pain, anxiety, stress etc will make it tight (hard to relax). Slow and steady is the best way to go here. Do not proceed if there is severe pain as it will cause anticipatory contraction of the muscle next time.
There are no safe medications recommended. (although nifedipine and NO containing medications are used sporadically ). Trial and error would be the best method to go.
Hope this helps
feel free to ask followups