Well in 2001 i had no problems and had a negative AMA test. I was then given a double overdose of rifinah for seven and a half weeks 1200mg rifampicin per day and 600mg isoniazid per day. After this i was very weak and ill and i was left with hepatits that lasted 6 months and a positive AMA test since diagnosed as PBC. I have also had POTs syndrome and some other ilnesses come on shortly after. I have found numerous reports sugesting a link between these events and i am looking for some further information. Thank you.

So is it possible that the Isoniazid may have triggered pbc or that the drug induced hepatitis may have triggered it? AMA negative before overdose and positive after overdose.

It is the m2 antigen. The research i have done involving apoptosis, caspase 3 and oxidative stress seem to suggest a link is there. When you consider that a healthy man in his early 30s has developed pbc (a liver condition that mainly women get) just after an overdose of a liver damaging drug which induced chronic hepatitis. it seems that there would be a link there. thanks