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Treatment of ejaculation failure post Sertraline Use

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Hi I forgot to ask this question in prior posts but what are the options to treat Ejaculation failure caused by Sertraline use? I am going to see my Psychiatrist in two weeks and wanted to get a different perspective before I speak with him.


Category: Family Physician-GP

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Category: HIV- AIDS Specialist
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More than 35 percent of the patients on SSRIs for depression and anxiety have reported anorgasmia or delayed ejaculation as a common side effect. Such effects can sometimes be reversed by medications like Cyproheptadine,which is an antiseronergic. Yohimbine has also been tried with limited success.

I can understand it's causing a lot of stress to you. It's best to mention everything to your psychiatrist and he will help you further. There have been reported cases where after stopping the drug patient had normal orgasms again.

If you have any further queries do get back to us.


Patient replied :

Great thanks for the insight I will speak to my doctor and figure this out. I was curious as to whether Vibbryd is really something diffrent from the the SSRI's? I know for instance that it has SSRI properties and it serveres as a Sertonin antangonist. I was curious if this is just another case of Forrest lab losing its patent for Lexapro and trying to market another patened drug or if their is some validity to the new drug.
Additionally,are there really signinficant benefits from Celexa to Lexapro? I have read there are no diffrences in efficacy and side effects and that Lexapro was a patent extender. I have also read that it is more potent and has less side effects.

Just curious.

Thanks for wrtiting to us again.

No celexa and Lexapro are both SSRIs, however they are not interchangeable. Now prescription wise only Celexa is available. They have the same effects. No such scientific evidence, but Celexa is the preferred drug.

Vibbryd is SSRI, but it is only given in major depressive disorders.

Do get back to us for additional queries.


Patient replied :

Thank you for the reponse.

In Summary, your saying there is no diffrence between Celexa and Lexapro from an efficacy standpoint for Depression and Anxiety as well as side effects or is there? I have combined depression and anxiety and I am curious if there really is a diffrence between the two?


Thanks for posting your query.

Its great to find such patients who are so inquisitive and want to be aware of everything. There are various studies weighing the pros and cons of both, both nothing has been conclusive. All i can say is that Celexa is more preferred drug now. Celexa is used for major depressive disorders, with improvements expected in even anxiety disorders. It has also been used in some cases to delay ejaculation.

When it comes only to anxiety, Lexapro is the main drug used for Generalized Anxiety Disorder.

Both of them have similar side effects profile. Lexapro can lead to suicidal thinking in the future, which has been reported in a few cases. However commonly, the side effects are the same.

Hope that answers your query.


Patient replied :

Thanks for all of your help with these matters. I am currently taking Buporipon XR as an add on to the Sertraline for the ejaculation disorder and it has worked very well.

As far as Buporipon I have read that it has been used off labile to treat anxiety symptoms and in some studies it was efficacious as Lexapro for Generalized Anxiety Disorder. I was wondering if that is true? Additionally, is Buporipon a stimulant similar to a ritalin or riddlin? I know its a Norepeinephrine and Dopamine reuptake inhibitor and was just curious if it was an amphetamine derivative.

Thank you so much for your help.

Good to hear that your condition has been successfully treated.
I have not come across such studies but the general rule is if these claims are proven, it would be labelled for use in Generalized Anxiety Disorder.
Bupropion has a stimulant action but it is not a derivative of amphetamine. It is a relatively weak inhibitor of the neuronal uptake of norepinephrine and dopamine, thus having a mild stimulant effect.
I hope that answers all your questions.
Thank you.

Dr. Jaydeep Tripathy
Category: HIV- AIDS Specialist
MBBS from Sri Ramachandra University in December 2011
M.Med (Family Medicine) - TNMGR University, Chennai
MBA-MPH in Public Health in March 2016, SRM University
Finished AFIH in March 2016, SRM University
MRCP ( UK ), Internal Medicine, Royal College of Physicians, June 2016
Fellowship in Diabetology from Martin Luther University in January 2017

Currently Resident Physician, in MD Radiodiagnosis - Kamakshi Memorial Hospital, Chennai
Dr. Jaydeep Tripathy and 4 other Medical Specialists are ready to help you

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