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Elevated PROLACTIN, CHOLESTROL level in blood. MRI.

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Hi my wife just received these lab test results and one doctor told us to do an MRI because of the elevated prolactin level combined with cholesterol.

Category: Allergy and Immunologist

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Category: Diabetologist
 31 Doctors Online

Thanks for your query at
I understand our concern. I have gone through your reports.
But, I would like to a few things before I can interpret the results.
What is the age of the patient?
married/ unmarried?
Obstetric history?Number of children if any?
Any other medical history? Taking any medications?
What are present symptoms? Duration of current symptoms?
Please get back to me with answers.

Patient replied :

Thanks for the reply Dr

The patient is 43
no children
suffers from anxiety takes xanex (Took .5 mg 8 to 12 hours before blood test)
no symptoms. Had a blood test as part of a spa health plan.

Thanks for getting back.
Hyperprolactinemia (elevated levels of prolactin) may be due to a number of conditions. These conditions include pregnancy, hypothyroidism, stress, history of chest wall surgery, in patients with cirrhosis.
Some drugs such as alprazolam (xanex) may also be a cause of high prolactin levels
Another cause is a prolactin-secreting small tumor in the pituitary gland. It is a small tumor which can be easily removed by surgery. Your doctor has advised MRI for the same reason. Please get those investigation done as advised to exclude the condition.

Patient replied :

Thanks for the reply Dr.

We would like your opinion on a few points please:
Since the blood was drawn close to taking the xanex, should we have it taken again? We read it's best to take it 3 times to confirm the elevated Prolactine ?
What is the norm for prolactin levels ? Are they the same across different countries I.e. Caucasian, middle eastern etc)

Yes, please do the test again without taking Xanax and with the consultation of your psychiatrist. But, levels above 260 are indicative of prolactinoma. So, MRI is highly recommended.
I don't think lab values vary significantly across different races. But, lab values are dependent of laboratory methods of estimation.

Dr. J Muthukrishnan
Category: Diabetologist
1. 10th Asia-Pacific Pediatric Endocrine Society  Fellows meeting, Seoul, Korea, Oct 2008
2. Eighth ICMR Course on Genetics and Genetic Counseling – Jul 2008 – SGPGI, Lucknow
3. Annual Certificate Course on Endocrinological Laboratory Techniques at National Institute of Nutrition (ICMR) Hyderabad,India, ( Aug-Sep 2006) 
Fellowship: Endocrinology, Diplomate of National Board, National Academy of Medical Sciences, New Delhi, 2008, Medwin Hospital, Hyderabad
Senior Residency: Diplomate of National Board (General Medicine), National Academy of Medical Sciences, New Delhi, 2002
Residency: MD, General Medicine, 1997-2000, Armed Forces Medical College, 2nd position in University
Medical School: MBBS, Armed Forces Medical College, 1992
Dr. J Muthukrishnan and 4 other Medical Specialists are ready to help you

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