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High ESR, CRP with negative RHEUMATOID FACTOR. Cause?

Resolved Question:

I did lab test for ESR and CRP and both are high and i did rhomitoid factor and was negative please advise

Category: Internal Medicine Specialist

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Category: HIV- AIDS Specialist
 28 Doctors Online

Thank you for your query at
I understand your concern.
You need to elaborate on your symptoms before I can comment on these results. Both ESR and CRP and inflammatory markers, and non-specific.
Your ASO is also raised, which indicates a streptococcal infection. So, once your tell me about your symptoms, I will get back to you.

Patient replied :

I feel my forefoot cold and my hand as well

Is it always cold or gets cold on exposure to extreme temperature?
What are your other symptoms?
You also need to get a CBC test done.

Patient replied :

Its get cold when exposed to extreme temperature I can not walk without help and its difficult to move iam diabetic but recently I control it ,,,

Diabetic Neuropathy can have similar symptoms.
I can comment based on your recent CBC, FBS, PPBS, and HBA1c reports.
ASO titre is suggestive of a streptococcal infection recently.
Any difficulty in urination/ fever/ rash/ or viral symptoms?
Kindly get the tests done and share the reports with me,

Dr. Jaydeep Tripathy
Category: HIV- AIDS Specialist
MBBS from Sri Ramachandra University in December 2011
M.Med (Family Medicine) - TNMGR University, Chennai
MBA-MPH in Public Health in March 2016, SRM University
Finished AFIH in March 2016, SRM University
MRCP ( UK ), Internal Medicine, Royal College of Physicians, June 2016
Fellowship in Diabetology from Martin Luther University in January 2017

Currently Resident Physician, in MD Radiodiagnosis - Kamakshi Memorial Hospital, Chennai
Dr. Jaydeep Tripathy and 4 other Medical Specialists are ready to help you

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