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Is the girl fit for marriage with attached report?

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Please find the report attached and let me know whether the girl is fit for marriage or not and how her behaviour would be like and how her mental condition would be like and how about after she gets pregnant and children are born. In simple, whether she will be fit for family life or not?
Thank you for the advice.

Category: Pediatrician

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Category: ICU/ Critical Care Specialist
 31 Doctors Online

Thank you for your query at
Pure red cell aplasia is a broad diagnosis. It means that a person's bone marrow (our body's blood producing factory) is unable to produce the red blood cells required for carrying oxygen in the blood. There are many aetiologies/causes for this condition. Some of the aetiologies are genetic/hereditary and a few others are acquired causes.
It is not clear as to what the aetiology in her case is. Her blood reports suggest that her bone marrow seemed to be functioning adequately in 2008 (when the test was done). Do you have any more details about her condition? It would help me explain to you better.
Dr. Saptharishi L G
Dr. Saptharishi L G

Patient replied :

Sir: Thanks for the answer. I doubt whether her thoughts will be normal or not as she does things as she like, will not talk anything and if questioned, she simply leaves the house. I cannot tell whether her mental health is normal or not. What will be the case of the children if at all she becomes pregnant? It is a known fact that they used to inject blood from relatives or some others. What is the chance that it can repeat again? Can I lead a happy life with such a girl? Thank you.

Illnesses such as pure red cell aplasia are very difficult to deal with. Many children with this disease go through a lot of difficulties during their childhood period. It so happens that these children grow up to be really strong-willed adults with an ability to face any situation. One cannot comment upon her behaviour and character based on her underlying Pure red cell aplasia.
To correlate her blood transfusions and her pure red cell aplasia with her mental health is not entirely appropriate. These two are independent of each other. A person who is perfectly healthy may not have a pleasing character and vice versa. In fact, there is NO evidence to say that children with pure red cell aplasia are prone to any mental disorder. That is beyond the scope of my discussion. So I ll keep my comments to a purely medical perspective:
1. PRCA could be an inherited or an acquired disease. Acquired causes include VIRAL infections (parvo B 19). No one can control such things. Assume that you develop fever and the next thing you know, your body stops producing red blood cells. That is called acquired PRCA. It can happen to anyone. To blame a person for developing this infection and to question her character based on it would be foolish. If she has such an acquired variant, she may not transmit the bad genes to her children.
On the other hand if her PRCA is inherited, this girl's condition would best fit into - DIAMOND-BLACKFAN anemia. Some of these PRCA aetiologies are inherited via autosomal dominant mechanism. Meaning, if this girl actually has an inherited PRCA (There is no evidence to say whether she has acquired/ congenital variant of PRCA; I am only assuming the worst case scenario here), then 50% chance that her children may develop a PRCA during their childhood.
My sincere advice to you is to get her tested for genetic causes of PRCA. Clues to underlying inherited cause could be abnormal facial features, abnormal thumb or fingers, etc. Both of you need to speak to a geneticist.
Now, let me venture beyond medical facts with my personal advice:
PRCA can also develop in adult women after marriage especially during pregnancy. What if you marry someone and that person develops PRCA during pregnancy? You cannot control everything in life dear friend. Either you like this girl enough to spend the rest of your life with her or you don't. It is as simple as that. Do not bring her PRCA into this.

Patient replied :

Thank you very much for your advice dear doctor sir. What you said is absolutely fine but the only issue is with elders where I have to manage with both wife and mother and I do not know much on this subject and so had to contact people like you for this reason and it has been a great pleasure to discuss this with you and for your valuable suggestion. So what you say is do not think much on this issue and continue in marriage life with the girl and what I have understood from what you said is, behavior has nothing to do with PRCA. Hope to listen back from you soon.

I am glad that you are planning a life together. I suggest that both of you visit a geneticist with all her medical records and plan a genetic/chromosomal analysis to detect any abnormal gene. If there is no inherited cause detected, then you can peacefully go ahead with marriage. Her behaviour/attitude has nothing to do with her PRCA, in my opinion.
Wishing the two of you a wonderful life ahead.

Patient replied :

Hi doctor sir! Actually we both were married a year back and we got this information six months ago from her mother. So I have been concentrating very much on this issue. What do you think is better to do at this point of time? Thank you.

In that case I suggest that you consult a geneticist before you plan your child.
Wish you a happy married life.

Dr. Saptharishi L G
Category: ICU/ Critical Care Specialist
Senior Residency: DM,  Pediatric Critical Care, PGIMER

Residency: MD, Pediatrics, Postgraduate Medical Education & Research (PGIMER), Chandigarh, 2013

Internship: JIPMER, 2009

Medical School: MBBS, Jawaharlal Institute of Post-graduate Medical Education & Research (JIPMER), Puducherry, 2008
Dr. Saptharishi L G and 4 other Medical Specialists are ready to help you

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