Helped Over 500,000 patients with 98%+ satisfaction.

Connect & Get Personalized 1-to-1 Answers from Expert Doctors

DoctorSpring > Question Home

On meloxicam for lower leg pain developed severe ankle swelling

Resolved Question:

I was prescribed meloxicam for lower leg pain. Within days, my ankles swelled and became extremely painful, even having me resort to using a walker a few mornings to get going. (I am 48). My doctor sent me for numerous bloodtests (including auto immune marker) and a chest xray, after a consulting doctor mentioned sarcoidosis/lofgrens. Everything came back good, but I continued to get worse each day. I decided to stop the meloxicam and go back to ibuprofen. Within an hour, my pain was greatly reduced. Each day my ankle swelling went down a little more. It has been eight days, and one ankle is normal, while the other one is close. If I am on my feet long though, the swelling returns in one. Last night I noticed four nodules on my shins...two on each. I read this could be both a reaction to medication and also a symptom of sarcoidosis. I have not shared this info with my doctor yet, as his office is closed till Monday. He wants to still pursue the sarcoidosis and wants me to have a CT scan. I, however, am thinking my aggregated symptoms are from the meloxicam, and should maybe hold off a little bit on any additional tests. Im hesitant with the sarcoidosis, seeing bloodwork and chest xray are all good. Whatever my issue is.......its not showing up in bloodwork. He has run every test, all normal....which is why I think its the RX. I did, however, awake with leg pain, which is what put me on the meloxicam in the first place. I would appreciate any guidance or suggestions, and also know what type of doctor specializes in lower leg pain if this does not subside. I have been going to my primary care physician.

Category: Family Physician-GP

Ask Your Own Question

Category: HIV- AIDS Specialist
 25 Doctors Online


Thank you for asking your query at DoctorSpring.

I have gone through your query thoroughly. Please allow me to list down my initial thoughts and opinions for clarity.

1. Stop Meloxicam altogether. And if the pain is not very troubling you can stop the pain meds (NSAIDs). The leg swelling is a know side effect of these medication and the best way to confirm it is by withdrawing the medication.
2. Personally I would not consider the Diagnosis of Sarcoidosis at this stage. ( Please note I am saying with very limited medical history, investigation and without a clinical examination, but still)
3. I would consider a DVT (Deep Vein thrombosis) and rule it out as priority
4. Rather than a CT scan I would prefer a Doppler study of the lower leg
5. There are three major causes for the pain – A nerve problems, a vein / artery problem, a musculoskeletal problem. It has to be approached in a step wise manner. A neurological examination can rule out or confirm nerve problem. Other two will require some tests.

At this stage I would like to know some additional information from you :

1. Where exactly is the leg pain ? Back of leg ? or At the ankles ?
2. Is there any back pain ? (in the lower back )
3. Is there any weakness ?
4. Will pain increase or subside if you walk for some distance ?
5. The swelling happened only after taking the meds. It was not there to start with, am I correct ?

You can reply as a followup
Hope this helps
Thank you

Patient replied :

Dear Dr. Sebastian,

Thank you so much for your reply. Below are the answers to your questions:
- The pain started in my calves and shins, but is now in my lower shins, and ankles. The calf pain is non existent at this point.
- I do not have any back pain.
- I do not have any weakness.
- The pain is worse in the morning, or after sitting. The more I walk, the lesser the pain is. (This morning upon rising, the pain in my lower shins was more than it has been.)
- I did not have any swelling before taking the medication. I have totally stopped the meloxicam and have been alternating between tylenol and ibuprofen for pain. Now that the swelling has gone down, I will use tylenol if needed. This morning The pain is probably a 7 on a pain scale of 10.

I look forward to your reply and will research your suggestions in the meantime. Thank you so much!


Hello Denise

Thank you for providing the additional details.

Two main considerations here :

1. Claudication pain due to vascular blockage (block in artery or vein) (Vascular claudication / Intermittent claudication) - This has to be ruled out by checking the pulses on the leg (which your Doctor might have done already) and if needed doing a doppler study. The risk of this condition is high if you are a long term SMOKER.

2. Nerve compression - Can be identified by clinical examination and SLR (straight leg raising test).

Remember these two conditions are less likely in your case. But since both of these conditions need early treatment it has to be ruled out first. Probably the pain is due to musculoskeletal cause which will resolve itself by pain medications. The swelling is probably a medication side effect. Take some rest, and you can Tylenol is there is much pain

Hope this helps
Please DO feel free to ask followup questions.

Thank you

Patient replied :

Thank you for your added suggestions. I am going to mention these items, as well as your original suggestions, to my doctor, as they are all ones he has not talked to me about. I am hopeful my issue is the musculoskeletal one you mentioned that could clear up on its own. I am so thankful for your input. I will definately recommend this website to others.

Dr. Jaydeep Tripathy
Category: HIV- AIDS Specialist
MBBS from Sri Ramachandra University in December 2011
M.Med (Family Medicine) - TNMGR University, Chennai
MBA-MPH in Public Health in March 2016, SRM University
Finished AFIH in March 2016, SRM University
MRCP ( UK ), Internal Medicine, Royal College of Physicians, June 2016
Fellowship in Diabetology from Martin Luther University in January 2017

Currently Resident Physician, in MD Radiodiagnosis - Kamakshi Memorial Hospital, Chennai
Dr. Jaydeep Tripathy and 4 other Medical Specialists are ready to help you

Users who read this, also read:

Make informed and better medical decisions.

Join the 500,000 people who found a smarter, quicker way to get Answers, Recommendations & Expert Opinions.

Expert Doctors at fingertips

Recommendation on next step. Second-opinion.Multi-specialty.

Save Time

Average time for answers: 6 hours.

Save Money

$35 for typical specialist consult vs. $120 for a local appointment.

Free Follow-ups

Clarify, ask further questions for free in private conversation.

100% Satisfaction

Money back guarantee for the 1st reply. MEDNET Quality Board.

Start My Consultation



Doctor Spring is a novel online Doctor consultation platform where you can get your medical questions answered by leading Doctors. Just Submit your question and rest assured that you will consult a Doctor easily. Once you submit the question, the Doctor from the concerned specialty will reply within hours. You can always ask more questions or add details with follow-up question options and make it an online doctor chat. You may use this service to consult a specialty or for getting medical second opinion. All paid services come with a MEDNET quality assurance and 100% money back guarantee.

DoctorSpring in news