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This is query regarding a 10 yr old baby having congenital defect of caudal regression syndrome..Her weight is 12 kgs. She frequently gets UTI (fever, nausea etc) and she as taking the oral ofloxocin antibiotic.

Due to the urine incontinence which she has from birth, we have performed blood tests also for which the reports are gud but the Renal USG shows the hydroureteronephrosis of the kidnees for which we are worried.
Kindly suggest the best remedy to help avoid the UTI. Please note that she is on diapers all the time. Also need ur feedback and suggestions, mode of treatment looking at the current reports.

Category: Pediatric Nephrologist

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Category: Pediatric Nephrologist
Dr. Sree Bhushan Raju is online now

Expert:  Dr. Sree Bhushan Raju replied 4 Days.

Dear parent,
Thank you for your query at DoctorSpring.com

I can understand your situation. This is a challenging condition for the child as well as the family. Your child seems to have advanced bladder outlet obstruction with vesico ureteric reflux and chronic kidney disease.
There are a number of concerns regarding the current condition:
1. Recurrent urinary tract infections - These occur due to the stasis of urine inside the dilated portions of the urinary tract. This can be prevented by
a. antibiotic prophylaxis- usually with CO-TRIMOXAZOLE (SEPTRAN) daily to prevent UTIs
b. good genital hygiene practices such as wiping from front to back and never in the opposite direction, keeping the region dry and airy, avoiding continuous contact of wet, soiled diaper with genitalia (checking diapers infrequently, etc)
c. drinking plenty of fluids and preventing dehydration
d. Pharmacological measures such as urine alkalinizing agents may be tried but they are not of proven benefit.
e. Surgical options such as ureteric diversion procedures or percutaneous ureterostomy.
This situation is similar to a blocked drainage duct at home. Initially it would cause overflowing of foul contents in the bathroom. As the condition progresses, one would not be able to step into the house. Here, the bladder outlet seems to be blocked because of a spastic sphincter.. So the urine accumulates and dilates the urinary tract (ureter). As the back pressure worsens, kidneys are also afffected and they get thinned out. This condition is called HYDRO (abnormal urine accumulation in) -URETERO (ureter and)- NEPHROSIS (kidneys) [HDUN]
The problem is that once a child goes into established gross HDUN, there are very few options left. None of the options can reverse the condition completely as the kidneys are destroyed (thinned out). Over the years, child develops RENAL DYSFUNCTION --> KIDNEY FAILURE and becomes dialysis dependent.
Surgical options (urinary diversion procedures) may be considered on a case to case basis after assessment of baseline kidney functions. The tests that are recommended include DMSA scan to assess scarring and DTPA scan to assess function of kidneys. if there is residual function, then the procedures can be attempted after appropriate urodynamic studies on a case-to-case basis.
Please get DMSA/DTPA/ EC scans and get in touch with a pediatric surgeon.
Dr. Saptharishi L G

Dr. Sree Bhushan Raju
Category: Pediatric Nephrologist
FISN : Fellowship of Indian Society of Nephrology(ISN), 2012
FIACM : Fellowship of Indian Association of Clinical Medicin(IACM), 2012
FICP: Indian College of Physicians Association of Physicians of India, 2012
Fellowship: DM, DNB, All India Institute of Medical Sciences, New Delhi, 2002
Residency: MD, General Medicine, Nizam's Institute of Medical Sciences, 1998
Medical School: MBBS, Gandhi Medical College, 1994
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