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Sudden drop in temperature with chills on IBUPROFEN.

Resolved Question:

Hi I have a 2 year old with a 3 day fever (not ongoing but sporadic). We have been administering IBuprophen to regulate the high fevers (38+ C) and all swell until tonight we have noticed a large sudden drop in temperature and the apparition of cold sweats. (temp 35+ C). We are in a private ranch 80 clicks from the nearest healthcare.

Please advise on the course of action to take.

Thank you for your time and support

Category: Pediatrician

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Category: ICU/ Critical Care Specialist
 18 Doctors Online

Dear parent,
Thank you for your query at
I can understand your concerns. This is indeed a common scenario. Rapid defervescence (fall in temperature after a high grade fever) can fool the body into thinking that child is losing heat quickly. Hence the body starts constricting all skin blood vessels making the child feel cold and sweaty. This physiological phenomenon has been exactly described by you.
This can also happen rarely with overdose of anti-pyretic drugs. If a high dose of these drugs are accidentally ingested, a cold sweat phase develops with body temperature plummeting into hypothermia. What us the weight of your child? What dose of ibuprofen have you administered? What formulation did you use?
Dr. Saptharishi L G

Dr. Saptharishi L G
Category: ICU/ Critical Care Specialist
Senior Residency: DM,  Pediatric Critical Care, PGIMER

Residency: MD, Pediatrics, Postgraduate Medical Education & Research (PGIMER), Chandigarh, 2013

Internship: JIPMER, 2009

Medical School: MBBS, Jawaharlal Institute of Post-graduate Medical Education & Research (JIPMER), Puducherry, 2008
Dr. Saptharishi L G and 4 other Medical Specialists are ready to help you

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