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Why DDT, DIOXIN, PCB cannot be detoxified by liver?

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while I learning more about detoxification, I have two more questions. Although it is very rare in organic chemical compounds, there are such kinds of undetoxified or unbreakable chemical compounds such as DDT or Dioxin or PCB, is there any reason why these kinds of Toxin could not be detoxified by enzyme or liver (am i right? ) , are there any special chemical structures that hard to be broken by liver or enzyme. or there is no special enzymes to break or detoxify such kinds of toxin?

Seconds,(if there are alot of chemical structure that body could not break or detoxify) How could scientists know that the new chemical substances which they developed could be metabolized and broken into the parts or elements.... (what if it stay forever in the body)

last. as far as I know that all chemcial substances are not dangerous or lethal. because if the molecular structure of chemical substance is not simillar to hormone or not fittable to cell receptors, they could not block the function of cell or neuro system. (am I right? )
And then one toxin has the only one bad function to the receptors or cell? (is it possible for one toxin could do harm to several organs or cell or receptors..

P. S doctor teach me that toxin die with damaged cell together. It is very hard to understand because toxin molecure structrue could be changed by attacking cell or receptors?

Sorry to bother you again. Thank you very much.

Category: Neurologist, Medical

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Category: Pediatric Neurologist
 29 Doctors Online

Thank you for y.our query at
Toxins can be mostly metabolized by liver or enzymes. Some toxins bypass both these and are excreted by kidneys. Therefore, it is possible to do dialysis and remove these toxins.
Most toxins affect only one organ or system, however, some toxins can affect multiple organs or systems. For example, snake venom can affect blood as well as nerves. Lead can affect abdomen and nerves.
Some toxins if they are not removed can stay for ever. This includes mostly heavy metals. They need chelation therapy to be removed from the body.
Feel free to discuss further,
Best wishes,
Dr. Sudhir Kumar MD (Medicine), DM (Neurology)
Senior Consultant Neurologist

Patient replied :

Thank you for your answer. If toxin cannot be detoxified and stay in bone or fat, what is the next function of toxin. They do harm to body or cell forever until people die. Or there function stops when cells or receptors die connected. Thanks in advance.

Thank you for getting back.

Toxin may remain in he bone or fat for long, sometimes, from there, the toxin may travel to other organs through blood from there, resulting in harm to those organs.

Best wishes,

Dr. Sudhir Kumar MD (Medicine), DM (Neurology) Senior Consultant Neurologist

Dr. Sudhir Kumar
Category: Pediatric Neurologist
Senior Residency, Fellowship: DM, Neurology, CMC, Vellore, 2001
Junior Residency: MD, Internal Medicine, CMC, Vellore, 1998
Medical School: MBBS, Christian Medical College, Vellore, 1995
Dr. Sudhir Kumar and 4 other Medical Specialists are ready to help you

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