Thanks for your query at DoctorSpring.com.
The cream is completely absorbed into the circulation, and its effect stays for 48 - 72 hours, which is why it is prescribed over 2 - 3 days period.
The neo vagina that is fashioned after vaginoplasty does not resemble a 'normal' vagina in terms of shape and rugosity etc, hence it might not retain the cream that well, but rest assured, the hormone content gets absorbed within a few hours into the bloodstream.
The hormone is worked into a cream / gel base , and the hormone gets absorbed int he bloodstream, and what stays behind is the cream / gel, hence you get the feeling that it gets left behind.
Also, using vaginal estrogen increases your production of local secretions, hence the wetness might be confusing you too.
It cannot work its way back once it has been absorbed, do not worry about that.
Continue using it , as it would help in healing and epithelialization of the neo - vagina.
All the best.
Please feel free to ask for further clarifications.