Helped Over 500,000 patients with 98%+ satisfaction.

Connect & Get Personalized 1-to-1 Answers from Expert Doctors

DoctorSpring > Question Home

Absorption of vaginally applied Estrogen

Resolved Question:

I am a 27 year old female.

Is vaginally applied Estrace (estradiol vaginal cream) supposed to be absorbed completely, and if so, how long does it generally take? I was recently prescribed 1g Estrace cream to be applied vaginally every 3 days, however, it seems that the majority remains in the vaginal canal and does not absorb completely or just works its way back out over the next 2 ~ 3 days.

I was prescribed the estrace cream approximately 13 months post vaginoplasty due to recurrent bleeding during penetrative intercourse. The vaginal canal upon examination, prior to being prescribed the cream, was observed to be fully healed with no signs of open lesion or otherwise, and thus my gynecologist felt that the use of the medication would assist in creating more elasticity of the vaginal wall, which they felt was liking tearing during penetrative intercourse.

My vaginal canal produces very minimal amounts of secretion / moisture and I always require lubrication during any form of vaginal insertion. The vaginoplasty was primarily created out of skin graft material, and thus is not like that of a "normal" vagina. I have no ovaries, uterus or cervix present and rely solely on medication based hormones.

Category: OBGYN

Ask Your Own Question

Category: Infertility Specialist
 26 Doctors Online

Hello,

Thanks for your query at DoctorSpring.com.

The cream is completely absorbed into the circulation, and its effect stays for 48 - 72 hours, which is why it is prescribed over 2 - 3 days period.
The neo vagina that is fashioned after vaginoplasty does not resemble a 'normal' vagina in terms of shape and rugosity etc, hence it might not retain the cream that well, but rest assured, the hormone content gets absorbed within a few hours into the bloodstream.

The hormone is worked into a cream / gel base , and the hormone gets absorbed int he bloodstream, and what stays behind is the cream / gel, hence you get the feeling that it gets left behind.

Also, using vaginal estrogen increases your production of local secretions, hence the wetness might be confusing you too.

It cannot work its way back once it has been absorbed, do not worry about that.
Continue using it , as it would help in healing and epithelialization of the neo - vagina.

All the best.
Please feel free to ask for further clarifications.

Reagards


Dr. Aarti Vazirani
Category: Infertility Specialist
Experience: 
Residency: Obstetrics & Gynecolog, BJMC,Civil hospital, Ahmedabad, 2008
Post Graduate: MS (Obstetrics & Gynecology), B.J. Medical College, Ahmedabad, 2008
Medical School: MBBS, B.J. Medical College, Ahmedabad, 2004
Dr. Aarti Vazirani and 4 other Medical Specialists are ready to help you

Users who read this, also read:

Make informed and better medical decisions.

Join the 500,000 people who found a smarter, quicker way to get Answers, Recommendations & Expert Opinions.

Expert Doctors at fingertips

Recommendation on next step. Second-opinion.Multi-specialty.

Save Time

Average time for answers: 6 hours.

Save Money

$35 for typical specialist consult vs. $120 for a local appointment.

Free Follow-ups

Clarify, ask further questions for free in private conversation.

100% Satisfaction

Money back guarantee for the 1st reply. MEDNET Quality Board.

Start My Consultation

CHAT NOW

About DoctorSpring.com

Doctor Spring is a novel online Doctor consultation platform where you can get your medical questions answered by leading Doctors. Just Submit your question and rest assured that you will consult a Doctor easily. Once you submit the question, the Doctor from the concerned specialty will reply within hours. You can always ask more questions or add details with follow-up question options and make it an online doctor chat. You may use this service to consult a specialty or for getting medical second opinion. All paid services come with a MEDNET quality assurance and 100% money back guarantee.

DoctorSpring in news