Hello and thankyou for approaching DoctorSpring with your query.

Fish oil dosage around 3-4 gms is found to be beneficial in lowering triglycerides, LDL by 25 to 30 percent and increases HDL Thus having a benefit on the cardiovascular system in preventing Coronary heart disease. It is not that effective in lowering triglycerides when used in levels less than 2gms though has benefits.
Fish oil is also use by the brain cells, helps in anxiety. It is good for the joints too due to its anti-inflammatory effect.
It has shown to decrease systolic B.P by 3-5mmHg and diastolic b.p by 2-3 mmHg due to decrease in the resistance of the blood vessels in the body.
It helps in dry eye, by contributing to the lipid layer of the eye, therefore decreasing evaporation and of the maintaining the tear film.

Krill is supposed to be similar to DHA / EPA and provides similar benefits as well.

In small trials , fish oil capsules upto 12gm/day have been administered for more than 2 years without any serious adverse effects. However US FDA recommends general population to take upto 2g/day , and in patients with high triglycerides upto 4g/day. This recommendation is taking into consideration of all major evidence based studies. 2gm would be your safe bet. There is just not enough data for higher dosage.

Systematic reviews and meta analysis of numerous large studies have found no significant effects of fish consumption on any type of cancer. Hence the current overall study supports that fish or fish oil does not put you at the risk of cancer.

1) I would recommend you can continue your current dose. If your triglycerides are high , you can increase to 3gms, else the present dose is fine.

2) There is no way to test for oxidative damage. But fish oil is safe overall. And you need not worry if you taking around 203gm / day. Oxidative damage is a micro cellular process which can be measured.

Just a note regarding Vitamin E " Current evidence does not support a role for vitamin E supplementation in the prevention or treatment of cancers, cardiovascular disease, dementia, and infection. Since the best available evidence, while not conclusive, suggests that high-dose vitamin E (=400 units/day) might increase all-cause mortality ".

My recommendation is that you should NOT take Vitamin E supplement as there is possible risk (and no proven benefit). Another factor to be kept in mind is that Supplements have only a very small when compared to a good diet , exercise and weight loss. So make sure you are not overlooking the other factors

I hope this has helped.
Feel free to ask followups.

Thankyou

Sorry I meant 2gm only.
30 mIU of Vitamin E is not a concern. No issues there
The additional components may contribute EPA + DHA content in a non significant way. Many food items will also do the same. But that is acceptable since 2gm is the 'supplementary' dosage which takes other other possible sources into account.

Hope this clarifies
Feel free to ask followups
Thank you

In my opinion (which of course based on evidence and guidelines ) if you are a healthy individual ( WITHOUT - alcoholism, malabsorption, a vegan diet, a history of gastric bypass surgery, or some inborn errors of metabolism, hemodialysis , or a proven Vitamin deficiency) the only supplement to be considered is Fish Oil.

Now days testing for Vitamin D3 also makes sense. If Vitamin D3 is low then a Calcium _ Vit D supplement can be considered. There is no solid data which says extracted antioxidants in isolation are beneficial. Instead antioxidants in whole form as in fruits, vegetables, tea etc are the ones to be included.

So I would recommend any of them.

Hope this helps
Feel free to ask followups
Thank you

Hello,

At smaller doses Glutamine and Arginine are safe. At Least there is no evidence of any adverse effects. Many body building supplements have high levels of Glutamate , Arginine, L-Taurine, L-Carnitine, and L-Methionine. No adverse effects are usually reported. I really doubt the benefits , but I no issues taking them.

Vitamin D3 supplement is better taking after checking the Vit D3 levles. If you are not taking calcium you SHOULD NOT take this level of Vitamin D3 for sure.

In my opinion there is no reason for Magnesium and Potassium as the body will be able to adjust for any excess demand or loss. You can also check the Magnesium levels in the body to be sure.

Hope this helps
Thank you