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Constipation, exessive walking with ZYREXA, RISPIRDAL, DRUXAL.

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I am taking Zyrexa 15mg, Rispirdal Consta (injection) 37.5, and Druxal 150mg. Is taking all medcations together too much. I have constipation and exsisive walking. What is your opinion?

Category: Psychiatrist

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Thanks for posting your query at

I have gone through your question in detail and I can understand what you are going through. However before I proceed to answer your query, I have a few doubts.

1. For what illness are you being treated and since how long?
2. The problem of constipation and excessive walking. Since when are you having this problem?

Hope to hear these clarifications from you soon.
Kind regards
Dr. Srikanth Reddy MD

Patient replied :

Hello Dr.
I have this problem of phsychosis for 15 years old patientnow. I had this recent problem four months ago after a period of stopping taking my medication and now I am back although I had been taking seroquel before.

Thanks for the information.
Yes it is safe to take zyprexa and risperidone consta in the doses that you have mentioned. However the complains of constipation and excessive walking could be the side effects of the medicines that you are taking. Constipation is generally caused by olanzapine. You may take a high fibre diet and excessive water to help the problem. If required daily one spoon of ispaghula with plenty of water may be taken for the same. Excessive walking could be a side effect of risperidone as it causes akathesia. Propranolol may help in this condition in the dose of 40 mg to 80 mg.
Both the side effects that you are having are not serious and you may continue to take the medicines if they are helping you with your psychosis. However if the side effects are not tolerable then you may need to switch to aripiprazole or ziprasidone or quetiapine etc.
I am sorry but I could not get the name of the medicine ' Druxal' in the dose of 150mg. It seems it is available only in your country. Will it be possible for you to send me the details of the content of this medicine.
Hope this helps

Patient replied :

Thank you doctor,
As per Truxal it is chlorprothixene hydrochloride.


Thanks for the information. So it was truxal and not druxal. Yes in the dose of 150mg truxal is safe and can be taken with the medicines that you are already taking.
If your symptoms are well controlled with these medicnes then it is well and fine. However if the symptoms have not reduced totally then option of clozapine can be explored as it is used in resistant schizophrenia.
Hope this helps

Kind regards
Dr. Srikanth Reddy

Patient replied :

Thank you so much, I apreciate your replies and advise..Best Regards

Dr. Srikanth Reddy
Category: Sexologist
Doctor of Medicine (MD), Psychiatry Residency Program,2001 – 2012
M.B.B.S,Mahatma Gandhi Institute Of Medical Sciences, Sevagram

Certificate Course in sex Therapy and Counselling, Sexology and Counselling, A
Sexology,Medikon Sexual Sciences, Mumbai

Training in Advanced Neurology at a leading corporate hospital (CARE hospital) in Hyderabad

Child Psychiatry Training in National Institute of Mental Health and Neuro-Sciences, Bangalore

Sex Therapy and Counsellingat MEDIKON Sexual Sciences, Mumbai.
Dr. Srikanth Reddy and 4 other Medical Specialists are ready to help you

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