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Long acting Propranolol and codeine interaction

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I would like to know exactly how many mg propranolol 80mg LA long acting medication releases per hour or exactly how many mgs are released at what times and how many hours the total tablet or capsule or whatever lasts for. also is codeine ok to take at the same time as propranolol and will the effects of propranolol still be as effective? Let me know. Please answer both questions, really need the info. Thanks

Category: Internal Medicine Specialist

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Category: HIV- AIDS Specialist
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Hello,

Thank you for choosing DoctorSpring.

I would like to know whether you are require this information for a research purpose or a clinical purpose (as in for treatment).

If this is for a research purpose, I am afraid we won't be able to give specific and precise details as it seems data to that extend is not available in public domain. If this is regarding a clinical scenario (dosage , duration etc) we could surely help. If so we will require some clinical information of the patient.

Please let us know.
Thank you


Patient replied :

It's for research only. I want to know exactly what the information below means, that I've copied and pasted. I want you to try and answer my original question of about how many mg is released at what times. The information below should let you answer that, I don't understand it. Please let me know. I've also attached the link to the information if you need to look in to it more. Thanks again.


When measured at steady state over a 24-hour period the areas under the propranolol plasma concentration-time curve (AUCs) for the Inderal LA (propranolol) capsules are approximately 60% to 65% of the AUCs for a comparable divided daily dose of Inderal Tablets. The lower AUCs for the Inderal LA (propranolol) capsules are due to greater hepatic metabolism of propranolol, resulting from the slower rate of absorption of propranolol. Over a twenty-four (24) hour period, blood levels are fairly constant for about twelve (12) hours, then decline exponentially. The apparent plasma half-life is about 10 hours.


Pharmacokinetics And Drug Metabolism

Absorption

Propranolol is highly lipophilic and almost completely absorbed after oral administration. However, it undergoes high first pass metabolism by the liver and on average, only about 25% of propranolol reaches the systemic circulation. Inderal LA Capsules (60, 80,120, and 160 mg) release propranolol HC1 at a controlled and predictable rate. Peak blood levels following dosing with Inderal LA (propranolol) occur at about 6 hours.

Please try and answer my original question with using this information, thankyou

Here's the original link

http://www.rxlist.com/inderal-la-drug/clinical-pharmacology.htm


Hello,

Sorry we do not have the sufficient information and capacity to answer your consult. Hope you would understand. Please drop an email to [email protected] for a complete refund. Meanwhile if we come across any helpful information in this regard we will share it with you via this dashboard.
I am keeping this consult open for this purpose.

Sorry for the inconvenience.
Thank you


Patient replied :


Hello,

Sorry we do not have the sufficient information and capacity to answer your consult. Hope you would understand. Please drop an email to [email protected] for a complete refund. Meanwhile if we come across any helpful information in this regard we will share it with you via this dashboard.
I am keeping this consult open for this purpose.

Sorry for the inconvenience.
Thank you


Please note : The refund is being processed.



Dr. Jaydeep Tripathy
Category: HIV- AIDS Specialist
Experience: 
MBBS from Sri Ramachandra University in December 2011
M.Med (Family Medicine) - TNMGR University, Chennai
MBA-MPH in Public Health in March 2016, SRM University
Finished AFIH in March 2016, SRM University
MRCP ( UK ), Internal Medicine, Royal College of Physicians, June 2016
Fellowship in Diabetology from Martin Luther University in January 2017

Currently Resident Physician, in MD Radiodiagnosis - Kamakshi Memorial Hospital, Chennai
Dr. Jaydeep Tripathy and 4 other Medical Specialists are ready to help you

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